Location Details: Meet at Dolores Park (566 Dolores St. Although no unifying function has been defined for SRCR-SF members, accumulated data, together with the high degree of structural and phylogenetic conservation of SRCR domains indicates that they might subserve basic homeostatic functions, including innate immune defense. SF Scavengers Present The Bicycle Film Festival Scavenger Hunt Date: Thursday September 20: Time: 7:30 PM - 9:30 PM: Import this event into your personal calendar. Representatives of either group are found in different animal species, from low invertebrates (sponges) to high vertebrates (mammals). On the contrary, group B members generally present as proteins exclusively composed of tandem repeats of SRCR domains, with or without the presence of CUB and ZP domains thought to be involved in oligomerization but never associated to protease domains. Group A members usually present as multidomain mosaic proteins containing single SRCR domains associated to other functional domains, such as enzymatic (protease) domains or collagenous regions. Members of group A contain SRCR domains with 6 cysteine residues and are encoded by two exons, whereas those of group B usually contain 8 cysteines and are encoded by a single exon. The existence of two types of SRCR domains allows the division of the SRCR-SF into two groups.
The Scavenger Receptor Cysteine-Rich (SRCR) domain is an ancient and highly conserved protein module of ~100-110 amino acids, which defines a superfamily (SRCR-SF) of either soluble or membrane-bound receptors expressed by hematopoietic and nonhematopoietic cells, at either embryonic or adult stages.
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